The overarching goal of our research program is to discover, develop, and study new chemical reactions within the context of natural product total synthesis. Over the last century, natural products have played an essential role not only in medicine, but also in advancing the field of synthetic organic chemistry. Their complex architectures, reactive functional groups, and issues of stereochemistry provide a fertile setting for reaction development while exerting strict demands for selectivity and efficiency. Endeavors in natural product synthesis drive advances in the state-of-the-art in organic chemistry, and in so doing, impact a variety of research areas that integrate synthetic tools, from catalysis and materials science to biology.