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Drug Discovery

Researchers in our department are using chemistry to advance the study, diagnosis and treatment of disease.

Joshua Pierce works in his lab

Chemistry faculty are involved with highly interdisciplinary programs across the NC State campus and beyond to study the molecular basis of disease and to develop next-generation medicines.

One area of focus includes the discovery and development of drugs to combat the rapid emergence of multidrug-resistant bacterial pathogens. This is a global problem that has been recognized by the World Health Organization as one of the top three threats to global health.

Our faculty tackle this grand challenge to society and related problems by developing new synthetic methods to access new molecules, identifying biologically active compounds, understanding structure-activity relationships of small molecules, studying their mechanism of action, and using medicinal chemistry to fine-tune pharmacological properties.

Researchers in This Area

Wei-Chen Chang

Associate Professor, LORD Corporation Distinguished Scholar

Reza Ghiladi

Professor / Director of Graduate Programs / University Faculty Scholar

Jonathan Lindsey

Professor, Glaxo Distinguished University Chair

Dave Muddiman

Professor, Jacob and Betty Belin Distinguished Scholar, and Director of METRIC

Joshua Pierce

Howard J. Schaeffer Distinguished Professor of Chemistry and University Faculty Scholar

Gavin Williams

Professor / Department Head / LORD Corporation Distinguished Scholar