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Recent Publication

A graphic of BesC Initiating C–C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate
BesC triggers HAT to initiate C–C bond cleavage using a blue species. This represents an unprecedented reaction trajectory for a common diferric-peroxo intermediate employed by diiron enzymes

Haoyu Tang, a postdoctoral researcher contributing to the research efforts of the Chang Lab in the Department of Chemistry, has collaborated with the Makris Lab and other researchers to publish a new article in the Journal of the American Society.

The study shows that BesC activates O2 in a substrate-gated manner to generate a diferric-peroxo intermediate. Examination of the reactivity of the peroxo intermediate with a series of lysine derivatives demonstrates that BesC initiates this unique reaction trajectory via cleavage of the C4–H bond;

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