Jun Ohata

Area(s) of Expertise

Selective chemical reactions on natural proteins: Research in the Ohata group—leveraging expertise in organic/organometallic chemistry, protein science, bioconjugation techniques, fluorescence imaging, and biochemical analysis—focuses on (1) the development of chemical tools, especially protein labeling methods to study chemistry of proteins in living systems (e.g. mammalian cells and animal samples) and (2) the creation of functional protein conjugates with the chemical tools for material and medicinal applications.

Publications

• Chemical labeling strategies using biomolecule-compatible, nonaqueous media , (2023)
• Iron-sensitive protein conjugates formed with a Wittig reaction precursor in ionic liquid , CHEMICAL COMMUNICATIONS (2023)
• Iron-sensitive protein conjugates formed with a Wittig reaction precursor in ionic liquid , CHEMICAL COMMUNICATIONS (2023)
• A puromycin-dependent activity-based sensing probe for histochemical staining of hydrogen peroxide in cells and animal tissues , NATURE PROTOCOLS (2022)
• Correction to “An Ionic Liquid Medium Enables Development of a Phosphine-Mediated Amine–Azide Bioconjugation Method” , Journal of the American Chemical Society (2022)
• Phosphine-Mediated Three-Component Bioconjugation of Amino- and Azidosaccharides in Ionic Liquids , (2022)
• Phosphine-mediated three-component bioconjugation of amino- and azidosaccharides in ionic liquids , CHEMICAL COMMUNICATIONS (2022)
• Site-specific DNA functionalization through the tetrazene-forming reaction in ionic liquids , CHEMICAL SCIENCE (2022)
• Site-specific DNA functionalization through the tetrazene-forming reaction in ionic liquids (vol 13, pg 1780, 2022) , CHEMICAL SCIENCE (2022)
• Translation of a Phosphine- and Azide-Based Reaction to Chemical Modification of Biomolecules in Ionic Liquid , SYNLETT (2022)