Research Description

The Williams Lab is interested in combining the power of biology and organic chemistry to provide access to new complex organic molecules. More specifically, we leverage enzyme engineering, biocatalysis, metabolic engineering, organic chemistry, and synthetic biology to access and diversify the structures of natural products. These efforts form an innovative and powerful platform for drug discovery.

Publications

• Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase (2021)
• An artificial pathway for polyketide biosynthesis (2020)
• Cheminformatics Analysis and Modeling with MacrolactoneDB (2020)
• Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase (2020)
• SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides (2020)
• Synthetic biology enabling access to designer polyketides (2020)
• Synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis of isoprenoids (September, 10.1007/s10295-020-02306-3, 2020) (2020)
• Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids (2020)
• An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism (2019)
• Cover Feature: Probing the Substrate Promiscuity of Isopentenyl Phosphate Kinase as a Platform for Hemiterpene Analogue Production (ChemBioChem 17/2019) (2019)

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Education

B.Sc., Biochemistry, The University of Wales (1998)
Ph.D., Chemical Biology, University of Leeds (2002)