Gavin Williams
Professor / Department Head / LORD Corporation Distinguished Scholar
GLBT Advocate 2020-2021
Pronouns: (He, Him)
Dabney Hall 850
Education
B.Sc. Biochemistry The University of Wales 1998
Ph.D. Chemical Biology University of Leeds 2002
Area(s) of Expertise
The Williams Lab is interested in combining the power of biology and organic chemistry to provide access to new complex organic molecules. More specifically, we leverage enzyme engineering, biocatalysis, metabolic engineering, organic chemistry, and synthetic biology to access and diversify the structures of natural products. These efforts form an innovative and powerful platform for drug discovery.
Publications
- Targeted enzyme modifications enable regioselective biosynthesis of fluorinated polyketides , CHEM CATALYSIS (2022)
- Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase , NATURE COMMUNICATIONS (2021)
- Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics , ACS SYNTHETIC BIOLOGY (2021)
- Protein engineering for natural product biosynthesis and synthetic biology applications , PROTEIN ENGINEERING DESIGN & SELECTION (2021)
- Transcription factor-based biosensors: a molecular-guided approach for natural product engineering , CURRENT OPINION IN BIOTECHNOLOGY (2021)
- An artificial pathway for polyketide biosynthesis , Nature Catalysis (2020)
- Cheminformatics Analysis and Modeling with MacrolactoneDB , Scientific Reports (2020)
- Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase , (2020)
- SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides , Journal of Cheminformatics (2020)
- Synthetic biology enabling access to designer polyketides , Current Opinion in Chemical Biology (2020)