Dmytro Havrylyuk
Education
Ph.D. Pharmaceutical Chemistry and Pharmacology Danylo Halytsky Lviv National Medical University, Ukraine 2007
B.S. Pharmacy Danylo Halytsky Lviv National Medical University, Ukraine 2003
Area(s) of Expertise
Performs research in the Glazer Research Group to develop the new agents for traditional and photoactivated chemotherapies. Participates in numerous projects for synthesis and biological screening of small organic molecules and heteroleptic Ru(II)complexes as P450 inhibitors, PROTACs and inorganic anticancer agents.
Publications
- Fine‐Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity † , Photochemistry and Photobiology (2022)
- Ru(II) photocages enable precise control over enzyme activity with red light , Nature Communications (2022)
- Ru-PROTACs are a Promising Tool for the Photocontrol of Protein Degradation , Metals in Medicine, Gordon Research Conference (2022)
- Biological Investigations of Ru(II) Complexes with Diverse β‐Diketone Ligands , European Journal of Inorganic Chemistry (2021)
- Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes , Current Opinion in Chemical Biology (2021)
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Avobenzone incorporation in a diverse range of Ru(
ii ) scaffolds produces potent potential antineoplastic agents , Dalton Transactions (2020) - Photochemical and Photobiological Properties of Pyridyl-pyrazol(in)e-Based Ruthenium(II) Complexes with Sub-micromolar Cytotoxicity for Phototherapy , ACS Omega (2020)
- Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions , Photochemistry and Photobiology (2020)
- Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility Through Fine Tuning of Steric, Electronic, and Physiochemical Features , Inorganic Chemistry (2020)
- Ru(II) CYP1B1 Inhibitor Prodrugs with Enhanced Potency , Metals in Medicine, Gordon Research Conference (2018)