Dmytro Havrylyuk

Area(s) of Expertise

Performs research in the Glazer Research Group to develop the new agents for traditional and photoactivated chemotherapies. Participates in numerous projects for synthesis and biological screening of small organic molecules and heteroleptic Ru(II)complexes as P450 inhibitors, PROTACs and inorganic anticancer agents.

Publications

• The Impact of Inorganic Systems and Photoactive Metal Compounds on Cytochrome P450 Enzymes and Metabolism: From Induction to Inhibition , BIOMOLECULES (2024)
• Ru(II) photocages enable precise control over enzyme activity with red light , Nature Communications (2022)
• Ru-PROTACs are a Promising Tool for the Photocontrol of Protein Degradation , Metals in Medicine, Gordon Research Conference (2022)
• Biological Investigations of Ru(II) Complexes with Diverse β‐Diketone Ligands , European Journal of Inorganic Chemistry (2021)
• Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes , Current Opinion in Chemical Biology (2021)
• Fine‐Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity ^† , Photochemistry and Photobiology (2021)
• Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents , Dalton Transactions (2020)
• Photochemical and Photobiological Properties of Pyridyl-pyrazol(in)e-Based Ruthenium(II) Complexes with Sub-micromolar Cytotoxicity for Phototherapy , ACS Omega (2020)
• Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility Through Fine Tuning of Steric, Electronic, and Physiochemical Features , Inorganic Chemistry (2020)
• Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions , Photochemistry and Photobiology (2019)

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