Thomas Theis

Area(s) of Expertise

NMR and MRI are cherished for their molecular specificity and contrast rich images, but suffer from very low sensitivity. We develop hyperpolarization chemistry using para- hydrogen to enhance NMR and MRI signals by up to 6 orders of magnitude. This enables new applications such as portable NMR and cost- efficient molecular imaging.

Publications

• ¹³C MRI of hyperpolarized pyruvate at 120 μT , SCIENTIFIC REPORTS (2024)
• Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-¹³C]Pyruvate , ACS SENSORS (2024)
• Carbon‐13 Hyperpolarization of α‐Ketocarboxylates with Parahydrogen in Reversible Exchange , ChemMedChem (2024)
• Molecular NMR shieldings, J-couplings, and magnetizabilities from numeric atom-centered orbital based density-functional calculations , ELECTRONIC STRUCTURE (2024)
• SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR , JOURNAL OF MAGNETIC RESONANCE OPEN (2024)
• Toward Next-Generation Molecular Imaging with a Clinical Low-Field (0.064 T) Point-of-Care MRI Scanner , ANALYTICAL CHEMISTRY (2024)
• Toward Ultra-High-Quality-Factor Wireless Masing Magnetic Resonance Sensing , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2024)
• Zero to ultralow magnetic field NMR of [1-13 C]pyruvate and [2-13 C]pyruvate enabled by SQUID sensors and hyperpolarization , PHYSICAL REVIEW B (2024)
• C-13 Radiofrequency Amplification by Stimulated Emission of Radiation Threshold Sensing of Chemical Reactions , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
• Delivering Robust Proton-Only Sensing of Hyperpolarized [1,2-¹³C₂]-Pyruvate Using Broad-Spectral-Range Nuclear Magnetic Resonance Pulse Sequences , ACS SENSORS (2023)