Thomas Theis

Area(s) of Expertise

NMR and MRI are cherished for their molecular specificity and contrast rich images, but suffer from very low sensitivity. We develop hyperpolarization chemistry using para- hydrogen to enhance NMR and MRI signals by up to 6 orders of magnitude. This enables new applications such as portable NMR and cost- efficient molecular imaging.

Publications

• ¹⁵N SABRE-SHEATH and NMR/DFT Characterization of Amino-Metronidazole, a Metabolic Product of the Antibiotic and Prospective Hypoxia Contrast Agent Metronidazole , JOURNAL OF PHYSICAL CHEMISTRY B (2025)
• Front Cover: Carbon‐13 Hyperpolarization of α‐Ketocarboxylates with Parahydrogen in Reversible Exchange (ChemMedChem 5/2025) , ChemMedChem (2025)
• Photo-ejected ligands hyperpolarized by parahydrogen in reversible exchange , CHEMICAL COMMUNICATIONS (2025)
• RASER for Increased Spectral Resolution in Carbon-13 NMR , ANALYTICAL CHEMISTRY (2025)
• ¹³C MRI of hyperpolarized pyruvate at 120 μT , SCIENTIFIC REPORTS (2024)
• Carbon-13 Hyperpolarization of α-Ketocarboxylates with Parahydrogen in Reversible Exchange , CHEMMEDCHEM (2024)
• Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-¹³C]Pyruvate , ACS SENSORS (2024)
• Molecular NMR shieldings, J-couplings, and magnetizabilities from numeric atom-centered orbital based density-functional calculations , ELECTRONIC STRUCTURE (2024)
• SABRE-SHEATH Hyperpolarization of [1,5-¹³C₂]Z-OMPD for Noninvasive pH Sensing , ACS SENSORS (2024)
• SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR , JOURNAL OF MAGNETIC RESONANCE OPEN (2024)