Yi Xiao

Area(s) of Expertise

Dr. Xiao’s group works on applications of biosensors and biotechnologies at the interface of chemistry, biochemistry, and molecular biology. The main goal of her research is centered around the development of aptamer selection techniques and aptamer-based sensor platforms, and the use of such advancements to develop sensitive, specific, cost-effective assays and devices for detection of medically- and forensically-relevant small-molecule targets in real-world samples.

Publications

• Comparison of Aptamer Signaling Mechanisms Reveals Disparities in Sensor Response and Strategies to Eliminate False Signals , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
• Suite of Aptamer-Based Sensors for the Detection of Fentanyl and Its Analogues , ACS SENSORS (2023)
• Using Exonucleases for Aptamer Characterization, Engineering, and Sensing , ACCOUNTS OF CHEMICAL RESEARCH (2023)
• DNA Aptamer-Cyanine Complexes as Generic Colorimetric Small-Molecule Sensors , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)
• High-throughput quantitative binding analysis of DNA aptamers using exonucleases , NUCLEIC ACIDS RESEARCH (2022)
• Near-Infrared Dye-Aptamer Assay for Small Molecule Detection in Complex Specimens , ANALYTICAL CHEMISTRY (2022)
• Systematic Study of in Vitro Selection Stringency Reveals How To Enrich High-Affinity Aptamers , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
• Advances and Challenges in Small‐Molecule DNA Aptamer Isolation, Characterization, and Sensor Development , Angewandte Chemie International Edition (2021)
• Aptamer-Integrated Multianalyte-Detecting Paper Electrochemical Device , ACS Applied Materials & Interfaces (2021)
• Aptamers that bind to natural and synthetic cannabinoids , (2021)