Wei-Chen Chang
Assistant Professor
Pronouns: (He, Him, His)
Dabney Hall 525B
Education
Postdoctoral Research Fellow Chemistry Penn State 2015
Ph.D. Chemistry University of Texas at Austin 2011
B.S. Chemistry National Taiwan University 2003
Area(s) of Expertise
We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.
Publications
- A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
- Current Understanding toward Isonitrile Group Biosynthesis and Mechanism , CHINESE JOURNAL OF CHEMISTRY (2021)
- Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis , ACS CATALYSIS (2021)
- Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones , ACS CATALYSIS (2021)
- Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring , BIOCHEMISTRY (2020)
- An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2 , TRENDS IN CHEMISTRY (2020)
- Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
- Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
- A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases , BIOCHEMISTRY (2019)
- Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation , Organic Letters (2019)