Research Description

We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.

Publications

• Current Understanding toward Isonitrile Group Biosynthesis and Mechanism (2021)
• Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis (2021)
• Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring (2020)
• An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2 (2020)
• Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate (2020)
• Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases (2020)
• A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases (2019)
• Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation (2019)
• Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance (2019)
• Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships (2019)

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Education

Postdoctoral Research Fellow, Chemistry, Penn State (2015)
Ph.D., Chemistry, University of Texas at Austin (2011)
B.S., Chemistry, National Taiwan University (2003)