Wei-Chen Chang
Associate Professor, LORD Corporation Distinguished Scholar
Pronouns: (He, Him, His)
Dabney Hall 525B
Education
Postdoctoral Research Fellow Chemistry Penn State 2015
Ph.D. Chemistry University of Texas at Austin 2011
B.S. Chemistry National Taiwan University 2003
Area(s) of Expertise
We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.
Publications
- A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
- Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
- Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)
- Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis , ACS CATALYSIS (2022)
- Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate , NATURE COMMUNICATIONS (2022)
- Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
- Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
- Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
- A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
- BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)