Leslie Sombers

Area(s) of Expertise

The development, characterization and application of electroanalytical techniques to study real-time neurochemical fluctuations in systems ranging from single cells in culture to the brain of an awake, behaving animal. The ability to directly monitor these chemical messengers provides insight into the kinetics with which information is conveyed between neurons in response to environmental stimuli, the mechanisms that regulate these signals, and the behavioral implications of this neurochemistry.

Publications

• Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells , ANALYTICAL CHEMISTRY (2022)
• Virtual Issue: Neurotoxicology , ACS CHEMICAL NEUROSCIENCE (2022)
• Fast-Scan for In Vivo Measurements of Neurochemical Dynamics , The Brain Reward System (2021)
• Carbon-Fiber Nanoelectrodes for Real-Time Discrimination of Vesicle Cargo in the Native Cellular Environment , ACS Nano (2020)
• Interpreting Dynamic Interfacial Changes at Carbon Fiber Microelectrodes Using Electrochemical Impedance Spectroscopy , Langmuir (2020)
• Simultaneous voltammetric detection of glucose and lactate fluctuations in rat striatum evoked by electrical stimulation of the midbrain , ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)
• Drift Subtraction for Fast-Scan Cyclic Voltammetry Using Double-Waveform Partial-Least-Squares Regression , Analytical Chemistry (2019)
• Carbon-Fiber Microbiosensor for Monitoring Rapid Lactate Fluctuations in Brain Tissue Using Fast-Scan Cyclic Voltammetry , Analytical Chemistry (2018)
• Characterization of a Multiple-Scan-Rate Voltammetric Waveform for Real-Time Detection of Met-Enkephalin , ACS Chemical Neuroscience (2018)
• Electrochemical Selectivity Achieved Using a Double Voltammetric Waveform and Partial Least Squares Regression: Differentiating Endogenous Hydrogen Peroxide Fluctuations from Shifts in pH , Analytical Chemistry (2018)