Leslie Sombers

Area(s) of Expertise

The development, characterization and application of electroanalytical techniques to study real-time neurochemical fluctuations in systems ranging from single cells in culture to the brain of an awake, behaving animal. The ability to directly monitor these chemical messengers provides insight into the kinetics with which information is conveyed between neurons in response to environmental stimuli, the mechanisms that regulate these signals, and the behavioral implications of this neurochemistry.

Publications

• A Student Perspective on the 18th Monitoring Molecules in Neuroscience Meeting in Lyon , ACS CHEMICAL NEUROSCIENCE (2023)
• Exploiting Microelectrode Geometry for Comprehensive Detection of Individual Exocytosis Events at Single Cells , ACS SENSORS (2023)
• Monitoring Molecules in Neuroscience , ACS CHEMICAL NEUROSCIENCE (2023)
• Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells , ANALYTICAL CHEMISTRY (2022)
• Virtual Issue: Neurotoxicology , ACS CHEMICAL NEUROSCIENCE (2022)
• Fast-Scan for In Vivo Measurements of Neurochemical Dynamics , The Brain Reward System (2021)
• Carbon-Fiber Nanoelectrodes for Real-Time Discrimination of Vesicle Cargo in the Native Cellular Environment , ACS Nano (2020)
• Interpreting Dynamic Interfacial Changes at Carbon Fiber Microelectrodes Using Electrochemical Impedance Spectroscopy , Langmuir (2020)
• Simultaneous voltammetric detection of glucose and lactate fluctuations in rat striatum evoked by electrical stimulation of the midbrain , ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)
• Drift Subtraction for Fast-Scan Cyclic Voltammetry Using Double-Waveform Partial-Least-Squares Regression , Analytical Chemistry (2019)