Joshua Pierce
Associate Professor, LORD Corporation Distinguished Scholar and University Faculty Scholar
LORD Corporation Distinguished Scholar
University Faculty Scholar
Leader, Natural Products to Drugs Initiative (Comparative Medicine Institute, NC State)
Dabney Hall 840
Education
B.S. University of Pittsburgh 2003
Ph.D. University of Pittsburgh 2008
Area(s) of Expertise
We are employing synthetic chemistry to tackle problems in chemical biology and drug discovery. Through the development of novel reactions we aim to synthesize complex natural products and use targeted modifications to lend insight into their biological mechanism of action. Ultimately, these efforts will uncover novel drug lead compounds for further development.
Publications
- Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture , ACTA BIOMATERIALIA (2022)
- Tissue-reactive drugs enable materials-free local depots , JOURNAL OF CONTROLLED RELEASE (2022)
- Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B , BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)
- Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence , ACCOUNTS OF CHEMICAL RESEARCH (2021)
- Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach , TETRAHEDRON LETTERS (2021)
- Stereoselective Synthesis of the Spirocyclic gamma-Lactam Core of the Ansalactams , ORGANIC LETTERS (2021)
- 1,4-Oxazines and their Benzo Derivatives , Comprehensive Heterocyclic Chemistry IV (2020)
- Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
- Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020) , ChemBioChem (2020)
- Genetic Determinants of Salmonella Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog , Applied and Environmental Microbiology (2020)