Joshua Pierce
Associate Professor, LORD Corporation Distinguished Scholar and University Faculty Scholar
LORD Corporation Distinguished Scholar
University Faculty Scholar
Leader, Natural Products to Drugs Initiative (Comparative Medicine Institute, NC State)
Dabney Hall 840
Research Description
We are employing synthetic chemistry to tackle problems in chemical biology and drug discovery. Through the development of novel reactions we aim to synthesize complex natural products and use targeted modifications to lend insight into their biological mechanism of action. Ultimately, these efforts will uncover novel drug lead compounds for further development.
Publications
- Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B (2021)
- Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence (2021)
- 1,4-Oxazines and their Benzo Derivatives (2020)
- Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy (2020)
- Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020) (2020)
- Genetic Determinants of Salmonella Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog (2020)
- In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation (2020)
- Stereocontrolled Synthesis of (±)-Melokhanine E via an Intramolecular Formal [3 + 2] Cycloaddition (2020)
- Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds (2020)
- 5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (2019)
Education
B.S., University of Pittsburgh (2003)
Ph.D., University of Pittsburgh (2008)