Area(s) of Expertise

Performs research in the Glazer Research Group to develop the new agents for traditional and photoactivated chemotherapies. Participates in numerous projects for synthesis and biological screening of small organic molecules and heteroleptic Ru(II)complexes as P450 inhibitors, PROTACs and inorganic anticancer agents.

Publications

• Multifaceted Ru(II) arene systems for phototherapy display activity in lung cancer and melanoma , Photochemistry and Photobiology (2025)
• Photo-ejected ligands hyperpolarized by parahydrogen in reversible exchange , Chemical Communications (2025)
• Supramolecular self-assemblies of Ru( ii ) phototherapeutics: biological activity of micro- and nano-particles acting as reservoirs , Journal of Materials Chemistry B (2025)
• Photodynamic therapy photosensitizers and photoactivated chemotherapeutics exhibit distinct bioenergetic profiles to impact ATP metabolism , Chemical Science (2024)
• The Impact of Inorganic Systems and Photoactive Metal Compounds on Cytochrome P450 Enzymes and Metabolism: From Induction to Inhibition , Biomolecules (2024)
• Ru(II) photocages enable precise control over enzyme activity with red light , Nature Communications (2022)
• Ru-PROTACs are a Promising Tool for the Photocontrol of Protein Degradation , Metals in Medicine, Gordon Research Conference (2022)
• Biological Investigations of Ru(II) Complexes with Diverse β‐Diketone Ligands , European Journal of Inorganic Chemistry (2021)
• Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes , Current Opinion in Chemical Biology (2021)
• Fine‐Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity , Photochemistry and Photobiology (2021)

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