Daniel Comins

Area(s) of Expertise

The principal emphasis of Professor Comins’ research program is the development of new synthetic methodologies and strategies for the asymmetric synthesis of alkaloids, natural products and biologically active compounds. He is particularly interested in the design of new synthetic reactions, especially practical, high-yield methods for the synthesis of complex organic molecules with specific stereochemistry. Several strategies based on heterocyclic and organometallic chemistry are under investigation.

Publications

• Synthesis of MAPA Reagents and 2-Alkyl(aryl)aminopyridines from 2-Bromopyridine Using the Goldberg Reaction , MOLECULES (2022)
• Preparation of substituted alkoxypyridines via directed metalation and metal-halogen exchange , ARKIVOC (2021)
• Editorial for the Special Issue on Heterocycles , JOURNAL OF ORGANIC CHEMISTRY (2016)
• Studies toward the Synthesis of Lepadiformine A , JOURNAL OF ORGANIC CHEMISTRY (2016)
• Synthesis of C-4 Substituted Amido Nicotine Derivatives via Copper(I)- and (II)-Catalyzed Cross-Coupling Reactions , JOURNAL OF ORGANIC CHEMISTRY (2016)
• A concise synthesis of the Lycopodium alkaloid cermizine D , TETRAHEDRON LETTERS (2015)
• Novel approach toward the morphine skeleton. Synthesis of 1-(5-benzyloxy-2-bromo-4-methoxybenzyl)-6-oxo-3,4,6,7,8,8a-hexahydro-1H-isoquinoline-2-carboxylic acid phenyl ester via N-acylpyridinium salt chemistry , TETRAHEDRON (2015)
• A Twist on Facial Selectivity of Hydride Reductions of Cyclic Ketones: Twist-Boat Conformers in Cyclohexanone, Piperidone, and Tropinone Reactions , JOURNAL OF ORGANIC CHEMISTRY (2014)
• Studies toward the Total Synthesis of Dihydrolycolucine. Preparation of AB and CEF Ring Fragments , JOURNAL OF ORGANIC CHEMISTRY (2014)
• Total Synthesis of Alkaloid 205B , JOURNAL OF ORGANIC CHEMISTRY (2014)

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