Wei-Chen Chang
Associate Professor, LORD Corporation Distinguished Scholar
Pronouns: (He, Him, His)
Dabney Hall 525B
Education
Postdoctoral Research Fellow Chemistry Penn State 2015
Ph.D. Chemistry University of Texas at Austin 2011
B.S. Chemistry National Taiwan University 2003
Area(s) of Expertise
We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.
Publications
- A survey of C-C bond formation strategies and mechanism deployed by iron-containing enzymes in natural products , TETRAHEDRON (2024)
- New Frontiers in Nonheme Enzymatic Oxyferryl Species , CHEMBIOCHEM (2024)
- Optimized Substrate Positioning Enables Switches in the C-H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2024)
- Poly-γ-glutamylation of biomolecules , NATURE COMMUNICATIONS (2024)
- Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces , ACS CATALYSIS (2024)
- A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
- An S=1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)
- Current understanding of lignan biosynthesis , ARKIVOC (2023)
- Excision of a Protein-Derived Amine for p-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD , BIOCHEMISTRY (2023)
- Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)