Area(s) of Expertise

The Muddiman Group focuses on the development of innovative mass spectrometry measurements to solve important biological problems. Research projects include developing an ambient ionization method called IR-MALDESI and its application to a diverse range of materials, including soft tissue, plants, textiles and bone. Moreover, the group is working on advanced separations to enable detailed characterization of complex biological samples.

Publications

• Demonstrating Voxel‐by‐Voxel (V × V) Single‐Point Calibration in Whole‐Body Zebrafish by IR‐MALDESI Quantitative MSI , Journal of Mass Spectrometry (2026)
• Glycan signal enhancement by ammonium fluoride doping and electrospray diverting , The Analyst (2026)
• Glycan signal enhancement by ammonium fluoride doping and electrospray diverting , DRYAD (2026)
• High‐Throughput N ‐Glycan Analysis by IR‐MALDESI With a 1.5‐kHz Pulsed Mid‐IR Laser , Journal of Mass Spectrometry (2026)
• Integrating Remote Sensing and Metabolomics to Assess Synergistic Effects of Phosphate Deficiency, Drought, and AMF Symbiosis in Soybean , Physiologia Plantarum (2026)
• Resolving the glycosaminoglycan signature of ischemic stroke brain using PRM-based IR-MALDESI mass spectrometry imaging , Analytical and Bioanalytical Chemistry (2026)
• Spatially resolved lipids in a mouse brain model of globoid cell leukodystrophy via IR-MALDESI MSI and parallel reaction monitoring MSI , Analytical and Bioanalytical Chemistry (2026)
• A Strategy to Achieve Sub‐Parts‐per‐Million Mass Measurement Accuracy of N‐Linked Glycans Using Infrared Matrix‐Assisted Laser Desorption Electrospray Ionization , Journal of Mass Spectrometry (2025)
• Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes , Biomaterials (2025)
• Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes , bioRxiv (Cold Spring Harbor Laboratory) (2025)